Tuesday 23 May, 2006

Two minute overview of antipsychotics

Posted in Emergency Dept., General Practice, May Su, Psychiatry, Wards at 0:15 by May Su

Original article by: May Su :: Printer friendly

Antipsychotics can be classified as typical or atypical. There are very few reasons now where a typical would be used in preference to an atypical in first line treatment. Atypical antipsychotic medications generally have fewer side effects and are as effective (clozapine is more effective than most of the older antipsychotics).

Antipsychotics cause anticholinergic side effects and extrapyramidal side effects (EPSE).

The two main medical emergencies associated with use of antipsychotics are oculogyric crisis and neuroleptic malignant syndrome.

Risperidone (oral) is more likely to cause EPSE than the other atypical antipsychotics, although to a lesser degree than the typical antipsychotics.

Antipsychotics and their trade names available in Australia:

Atypical antipsychotics

  • amisulpride (Solian) – tablets and liquid
  • quetiapine (Seroquel) – tablets
  • olanzapine (Zyprexa) – tablets, wafer (Zyprexa Zydis), intramuscular injection (Zyprexa IM)
  • risperidone (Risperdal) – tablets, oral dissolving tablets (Risperdal Quicklet), liquid
  • aripiprazole (Abilify) – tablets
  • clozapine (Clopine, Clozaril, CloSyn) – tablets
    • not a first line treatment, highly specialised

Atypical antipsychotics – depot

Typical antipsychotics

Typical antipsychotics – depot

Remember that many of the typical antipsychotics or the “neuroleptics” are in the class of chemicals known as “phenothiazines“. Other commonly used medications that are phenothiazines but not generally used as antipsychotics (though nevertheless can have similar side-effects as the typical antipsychotics) include:

Resource: Antipsychotics in Australia

Updated: Michael Tam (12 September 2006)

Please read the disclaimer

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1 Comment »

  1. Michael Tam said,

    I received a letter today from Janssen-Cilag notifying the discontinuation of pimozide (Orap) in Australia. It is estimated that it will become out of stock by approximately October 2006.

    Pimozide will remain available under the Special Access Scheme (under the Therapeutic Goods Administration) for patients with “schizophrenia or a related disorder and whose treated condition is already stable with pimozide as the prescribed medication, and for who other medications have been ineffective or associated with adverse events”.


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